No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer

Autoři	FREIBERGER Tomáš RAVČUKOVÁ Barbora GRODECKÁ Lucie KUŘECOVÁ Barbora JARKOVSKÝ Jiří BARTOŇKOVÁ Dana THON Vojtěch LITZMAN Jiří
Rok publikování	2010
Druh	Článek v odborném periodiku
Časopis / Zdroj	Journal of Reproductive Immunology
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.1016/j.jri.2010.04.002
Obor	Imunologie
Klíčová slova	Neonatal Fc receptor; FcRn; VNTR; Polymorphism; Maternal-fetal IgG transfer
Popis	The neonatal Fc receptor (FcRn) plays a critical role in maternal-fetal IgG transfer. Recently, a functionally active promoter polymorphism in the FCRN gene, represented by variable number of tandem repeats (VNTR), has been described. We analysed 103 single fetal samples and 103 paired maternal and fetal samples collected from umbilical cord blood of full-term neonates born from the 38th to the 41st week of pregnancy and detected no significant influence of maternal FCRN VNTR genotype on maternal IgG levels or of fetal FCRN VNTR genotype on fetal IgG levels or the fetal/maternal IgG ratio.