Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency

Autoři	FREIBERGER Tomáš GRODECKÁ Lucie RAVČUKOVÁ Barbora KUŘECOVÁ Barbora POSTRÁNECKÁ Věra VLČEK Jiří JARKOVSKÝ Jiří THON Vojtěch LITZMAN Jiří
Rok publikování	2010
Druh	Článek v odborném periodiku
Časopis / Zdroj	CLINICAL IMMUNOLOGY
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.1016/j.clim.2010.05.006
Obor	Genetika a molekulární biologie
Klíčová slova	Neonatal Fc receptor; FcRn; Common variable immunodeficiency; Lung disease; IVIG
Popis	Patients with generalized bronchiectasis and fibrosis had lower levels of FCRN mRNA compared to patients without these complications. Moreover, FCRN mRNA levels correlated negatively with the extent of bronchiectasis and the rate of IgG decline after infusion of IVIG.Our results showed that FcRn might play a role in the development of lung structural abnormalities and in the catabolism of IVIG in patients with CVID.