ACE gene insertion/deletion polymorphism has a moderate influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI

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PAŘENICA Jiří PÁVKOVÁ GOLDBERGOVÁ Monika KALA Petr POLOCZEK Martin MAŇOUŠEK Jan PRYMUSOVÁ Krystyna KUBKOVÁ Lenka JARKOVSKÝ Jiří TOMČÍKOVÁ D. TOMAN Ondřej TESÁK Martin TOMANDL Josef VAŠKŮ Anna ŠPINAR Jindřich

Rok publikování 2010
Druh Článek v odborném periodiku
Časopis / Zdroj BMC Cardiovascular Disorders
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Genetika a molekulární biologie
Klíčová slova ACE; polymorphism; gene; myocardial infarction
Popis We evaluated the associations among angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism, ACE activity and post-myocardial infarction left ventricular dysfunction and acute heart failure early after presentation with MI with ST-segment elevation. A total of 556 patients with STEMI treated by primary PCI were the study population. The DD/ID genotypes were associated with a significantly higher risk of EF. These results suggest that the I/D polymorphism of ACE is associated with the development of LV dysfunction in the acute phase after STEMI. We demonstrated for the first time an association of the low ACE activity with the severe LV dysfunction, although patients with moderate LV dysfunction had higher level ACE activity than patients with preserved LV function.
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