Neural stem cell marker nestin as a specific marker for plasma cells of multiple myeloma patients.
| Autoři | |
|---|---|
| Rok publikování | 2011 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | Nestin, a class VI intermediate filament protein, is considered to be a characteristic marker of multipotent proliferative precursors found in some embryonic and fetal tissues. Unexpectedly, our previous results confirmed nestin levels in mature CD138+ plasma cells (PC) of multiple myeloma (MM) by flowcytometry; significant differences were found between nestin levels in MM and individuals without any hematological malignancy. The purpose of this study was to analyze nestin protein in CD138+PC and CD138-bone marrow mononuclear cells (BM MNC) of MM patients and myeloma cell lines. Our analysis clearly confirmed presence of nestin protein in CD138+PC but excluded nestin in CD138-BMMNC of MM patients. These results indicate that nestin may be a tumor specific marker for MM. Nestin-positive myeloma cell lines (U266, MOLP-8)are suggested as a model for study of nestin functions in PC of MM patients. |
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