CYP2D6 phenotyping in clinical practice: serum or urine dextromethorphan/dextrorphan metabolic ratio?
| Název česky | Stanovení fenotypu CYP2D6 v praxi: metabolický poměr dextrometorfan/dextrorfan v séru nebo moči? |
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| Autoři | |
| Rok publikování | 2011 |
| Druh | Článek ve sborníku |
| Konference | 17th International Conference on Cytochrome P450 |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Farmakologie a lékárnická chemie |
| Klíčová slova | CYP2D6; phenotype |
| Popis | The aim of this work was to elucidate if CYP2D6 phenotyping by evaluation of molar dextromethorphan to dextrorphan metabolic ratio (MRDEM/DOR) in serum has the usability and reliability as the assessment of MRDEM/DOR in urine. We measured MRDEM/DOR in serum and CYP2D6 genotype in 51 drug-naive patients and investigated cut-off value for discrimination of poor metabolizers from extensive and intermediate ones. The correlation of serum MRDEM/DOR with urine MRDEM/DOR in 30 healthy volunteers was analysed in parallel. |
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