Molecular dynamics of ribosomal L1 stalk

Varování

Publikace nespadá pod Lékařskou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

Název česky	Molekulová dynamika ribosomálního L1 stalku
Autoři	KREPL Miroslav RÉBLOVÁ Kamila ŠPONER Jiří
Rok publikování	2011
Druh	Konferenční abstrakty
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
Popis	The ribosomal L1 stalk is assumed to play important role in releasing deacylated tRNA from ribosome. During elongation cycle, L1 stalk moves between three distinct positions in relation to large subunit, crossing a distance of up to 60 A. We performed molecular dynamics simulations of L1 stalk taken from structure of Thermus thermophilus ribosome. The simulations revealed significant structural changes in L1 stalk/tRNA boundary, which might be important in facilitation of tRNA release. We also observed coupling between L1 RNA and L1 protein movement in relation to tRNA, which suggests critical role of protein-nucleic acid interactions for L1 stalk function.