Cardio-Ankle Vascular Index in Heterozygous Familial Hypercholesterolemia
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Kardiovaskulární nemoci včetně kardiochirurgie |
| Klíčová slova | Atherosclerosis; Cardio-ankle vascular index; Familial hypercholesterolemia; Statins; Ezetimibe |
| Přiložené soubory | |
| Popis | Aim: The cardio-ankle vascular index (CAVI) is a new non-invasive marker of arterial stiffness and atherosclerosis. The purpose of this study was to compare CAVI in patients with heterozygous familial hypercholesterolemia (FH) and in healthy controls. Methods: 82 FH subjects (27 males, 65 females), aged 53.7 +/- 13.6 years without clinical symptoms of cardiovascular diseases and 359 healthy controls (121 males, 238 females), aged 43.9 +/- 14.9 years, were examined. CAVI was measured using the system VaSera (R) 1500. Results: CAVI in FH patients was significantly higher (8.0 +/- 1.4) than in healthy subjects (7.5 +/- 1.3) p=0.002; however, age, sex and BMI adjusted CAVI did not differ significantly (p=0.061) between the FH group (7.5, CI: 7.3; 7.7) and control group (7.7, CI: 7.6; 7.7). Conclusion: The study showed no significant difference in CAVI between heterozygous FH and healthy controls. |
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