Dental Development and Regeneration

The main focus of the research is fundamental aspects of developmental biology, which are then used to develop new approaches in regenerative medicine. As a central model system, the continuously growing teeth are used. They have an extraordinary capacity for regeneration and repair and serve as an excellent model for studying stem cell niche, differentiation processes or micropatterning of hard tissues. The state-of-the-art approaches for example, single-cell RNA sequencing, work with genetically modified organisms (lineage tracing, conditional knockouts, engineering of new genetically modified strains – in collaboration), advanced imaging, including 3D confocal or light sheet microscopy, super-resolution microscopy, scanning electron microscopy, gene expression assays and many others are used.