Embryonic and Induced Pluripotent Stem Cell

The research group investigates the mechanisms that ensure genomic stability and metabolic regulation in human embryonic and induced pluripotent stem cells, with a particular interest in modelling heart disease using these stem cell systems. With their unique ability to produce both copies of themselves (self-renewal) and other more specialised cell types (differentiation) every time they divide, stem cells, therefore, are essential to the maintenance of tissues such as blood, skin, and gut that undergo continuous turnover (cell replacement), and muscle, which can be built up according to the body's needs and is often damaged during physical exertion.