September 10, 2019

Jan Křivánek

 Research interest | Team | Funding | Educational activities | Positions | Publications

jan_krivanekJan Krivanek, PhD, MSc

PI, Assistant professor

Dental Development and Regeneration Research Group

Phone                  +420 549 49 5112


Research interest

Our lab is focused on dental development, stemness regulation, regeneration, reparation and hard tissue microstructure. We are fascinated by fundamental aspects of tissue pattering, regulation of continuous incisor growth and healing processes. Finally, our research interest targets on development of new state-of-the-art approaches for regenerative medicine.


Team members

tereza Josef Lavicky, MSc
PhD student
PhD talent awarded (JCMM); IGA MUNI awarded
dj Marcos Gonzalez Lopez, MSc
PhD student
lucie Vendula Fridrichova, DDS
PhD Student
livia Adam Bogdanovic
Master student
Vladislav Rakultsev Vladislav Rakultsev
Master student
livia Magdalena Kolouskova
Dentistry student
JCMM grantee – Thesis awarded 6th place nationally, 2020



!Postdoc position available!
We are looking for an enthusiastic and motivated postdoctoc with an interest in stem cell research, to join an interesting and ambitious project with international collaborations.
For more information please contact us and visit:

We are currently looking for motivated bachelor and master students with an interest in developmental biology and stem cell research willing to join a growing team of nice and friendly people, happy to work on cutting-edge topics and participate in international collaborations.



Current projects

  • Grant Agency of Czech Republic (GAČR): Mechanosensing as a control mechanism for tooth growth and dental tissue repair, 2022-2024
  • Grant Agency of Masaryk University, StartUp grant, 2022
  • Czech bioimaging grant, 2022
  • PhD talent JCMM award for Josef Lavicky, 2020-2023

Finished projects

  • GAMU High risk/High gain individual research project: Understanding of tooth developmental trajectories as a novel approach for dental regeneration, 2019-2021
  • Grant Agency of Masaryk University (Josef Lavicky), 2021
  • Institutional support by Faculty of Medicine MU for junior researchers, 2018
  • Support for high school student projects, SOC – JCMM, 2019
  • Czech bioimaging grant, 2019


Educational activities

Oral histology and embryology  (Faculty of Medicine, Masaryk University)
Research activities in dentistry (Faculty of Medicine, Masaryk University)

Selected publications

  • Lavicky, J., Kolouskova, M., Prochazka, D., Rakultsev, V., Gonzalez, M., Steklikova, K., Bartos, M., Vijaykumar, A., Kaiser, J., Porizka, P., Hovorakova, M., Mina, M., Krivanek, J. The development of dentin microstructure is controlled by the type of adjacent epithelium. Nov 16. 10.1002/jbmr.4471.J Bone Miner Res. 2021
  • Krivanek, J., Lavicky J., Bouderlique, T., Adameyko, I. Rapid Isolation of Single Cells from Mouse and Human Teeth. Oct 28;(176). J Vis Exp. 2021
  • Krivanek, J., Soldatov, R. A., Kastriti, M. E., Chontorotzea, T., Herdina, A. N., Petersen, J., Szarowska, B., Landova, M., Kovar Matejova, V., Izakovicova Holla, L., Kuchler, U., Zdrilic, I. V., Balic, A., Marangoni, P., Klein, O. D., Neves, V. C. M., Yianni, V., Sharpe, P. T., Harkany, T., Metscher, B. D., Bajenoff, M., Mina, M., Fried, K., Kharchenko, P. V., Adameyko, I. Dental cell type profiling reveals new stem and differentiated cell types in mouse and human teeth. Sep 23;11(1):4816. Nature Communications. 2020
  • Landova, M., Zahradnicek, O., Dumkova, J., Krivanek, J., Dosedelova, H., Kavkova, M., Zikmund, T., Gregorovicova, M., Sedmera, D., Kaiser, J., Tucker, A. S., Buchtova, M. Developmental mechanisms driving complex tooth shape in reptiles. Apr; 249(4):441-464. Developmental Dynamics. 2020
  • Vijaykumar, A., Ghassem-Zadeh, S., Vidovic-Zdrilic, I., Komitas, K., Adameyko, I., Krivanek, J., Fu, A., Maye, P., Mina, M. Generation and Characterization of DSPP-Cerulean/DMP1-Cherry reporter mice. Jul 4:e23324. Genesis. 2019
  • Krivanek, J., Adameyko, I., Fried, K. Heterogeneity and Developmental Connections between Cell Types Inhabiting Teeth. Jun 7; 8:376. Front Physiol. 2017
  • Li, L., Newton, P. T., Bouderlique, T., Sejnohova, M., Zikmund, T., Kozhemyakina, E., Xie, M., Krivanek, J., Kaiser, J., Qian, H., Dyachuk, V., Lassar, A. B., Warman, M. L., Barenius, B., Adameyko, I., Chagin, A. S. Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice. Mar; 31(3):1067-1084. FASEB J. 2017
  • Khatibi Shahidi, M.*, Krivanek, J.*, Kaukua, N., Ernfors, P., Hladik, L, Kostal, V., Masich, S., Hampl, A., Chubanov, V., Gudermann, T., Romanov, R. A., Harkany, T., Adameyko, I., Fried, K. Three-dimensional Imaging Reveals New Compartments and Structural Adaptations in Odontoblasts. Jul; 94(7):945-54. J Dent Res. 2015


The Beauty of Science

(awarded images)

Cover – Journal of Dental Research

Nikon small world: Image of Distinction – top100

The invisible body Art exhibition – Sven-Harrys museum (Stockholm, Sweden)
Imaris Snapshot