Predictive factors of multiple sclerosis relapse after the first demyelinating event: A 5-year follow-up

Kolčava J, Pelíšek O, Vlčková E.

Mult Scler Relat Disord. 2023 Mar;71:104566. doi: 10.1016/j.msard.2023.104566. Epub 2023 Feb 12. PMID: 36805172.


17 Apr 2023

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There is a growing need to discover the characteristics that predict prognostic factors after the first demyelinating event. In this study of 141 patients that met the 2017 McDonald criteria, a higher number of oligoclonal bands, cervical spinal cord demyelinating lesions, and sensory involvement were identified as independent predictors of the second demyelinating event during the 5-year follow-up period in patients who experienced the first demyelinating event. The identification of the aforementioned risk variables will make it possible to identify patients who are more likely to exhibit early second demyelinating event, implying more frequent monitoring and consideration of early application of highly effective disease-modifying treatment.

Keywords: Clinically isolated syndrome; Demyelinating diseases; Magnetic resonance imaging; Multiple sclerosis; Oligoclonal bands.

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