Prolonged survival in patients with local chronic infection after high-grade glioma treatment: Two case reports

Solár P, Mackerle Z, Hendrych M, Pospisil P, Lakomy R, Valekova H, Hermanova M, Jancalek R.

Front Oncol. 2022 Dec 16;12:1073036. doi: 10.3389/fonc.2022.1073036. PMID: 36591464; PMCID:PMC9800515.


6 Jan 2023

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High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant prolonged bacterial wound infection. The first patient treated for glioblastoma IDH-wildtype had been without disease progression for 61 months from the first resected recurrence. Despite incomplete chemotherapy-induced myelosuppression in the second patient with anaplastic astrocytoma IDH-mutant, she died without disease relapse after 14 years from the diagnosis due to other comorbidities. We assume that the documented prolonged survival could be related to the bacterial infection.

Keywords: anaplastic astrocytoma; glioblastoma; high-grade glioma; prolonged survival; wound infection.

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