Cytoskeleton Research
In the period 1998 to 1999 one of us (M.K.) was invited to take position as a Guest Professor at the Research Center for Pathogenic Fungi and Microbial Toxicoses Chiba University, Japan, to study the cytoskeleton in human pathogenic yeasts. This research continued in Brno supported by three grants of the Czech Grant Agency (310/00/0391, 310/03/1195, and 310/06/0605). Our present research is based on the contemporary knowledge of the functions of actin and microtubule cytoskeletons. In the area of basic research we study:
- actin and microtubule cytoskeletons in the selected strains of human pathogenic fungi;
- microtubules and F-actin involvement in budding, hyphal growth and conidiogenesis of fungi (Kopecká, Gabriel, Takeo, Yamaguchi et al., Eur. J. Cell Biol. 80:303-311 (2001); Kopecká, Gabriel, Takeo, Yamaguchi et al., Microbiology (UK) 149:865-876 (2003); Gabriel, Kopecká, Yamaguchi, Svoboda et al. Protoplasma 229:33-44 (2006)
- we are investigating the effects of actin and microtubule inhibitors on the cytoskeleton structure and the consequences for cell cycle (interphase, mitosis, cytokinesis), morphogenesis and pathogen proliferation (budding, hyphal development, conidiogenesis) (Kopecká, Gabriel, Takeo, Yamaguchi et al., Microbiology (UK) 149:865-876 (2003); Kopecká, Gabriel, Chemotherapy 2009;55:278-286; Kopecká et al. Chemotherapy 2010; 56:197-202)
- we are investigating the ultrastructural consequences of actin mutation in budding yeast (Yamaguchi, Kopecká, J. Electron Microsc. 59:141-152 (2010); Kopecká, Yamaguchi, J. Electron Microsc. 0:1-13 (2011).doi:10.1093/jmicro/dfr073
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