Research team
Marie Kopecká, Miroslav Gabriel and Augustin Svoboda belong to the most experienced researches of the department of biology, with almost 45 years of experience in the experimental cell biology. The present research is a continuation of previous projects on the yeast cell morphogenesis [GA CR 204/93/0667 (E.S.), GA CR 204/97/1150 (A.S.)] and investigation of the cytoskeleton in the human pathogenic yeasts initiated in Japan (M. Kopecká, a 7–month stay as a “Guest Professor” at Chiba University, Japan, Research Center for Pathogenic Fungi and Microbial Toxicoses) that continued in Brno, supported by grants of GA CR 310/00/0391 (M.K.), GA CR 310/03/1195 (M.G.) and GA CR 310/06/0605 (M.K.).
Marie Kopecká, M.D., Ph.D., Professor /e-mail/ studied the yeast exoskeleton (cell wall ultrastructure in budding and fission yeasts, ß-1,3-glucan microfibril nature, biogenesis and ultrastructure) and the yeast cytoskeleton. She initiated the research of the cytoskeleton in the human patogenic yeasts Cryptococcus neoformans, Aureobasidium pullulans, Fellomyces fuzhouensis, Malassezia pachydermatis and other fungi.
Miroslav Gabriel, M.D., Ph.D., Associate Professor († 2008) was a leading scientist in the area of cytoskeleton role in the yeast cell morphogenesis, the relation of mitosis, cytokinesis (septation) and the formation of the new cell wall. He was an expert in the microscopic techniques including time-lapse micro cinematography, fluorescent and electron microscopy. He also studied with Prof. Junpei Ishiguro, Kobe University, Japan yeast cps and actin mutants and the effects of actin and microtubule inhibitors on the yeast cells and filamentous fungi, especially on mitosis and cytokinesis.
Augustin Svoboda, M.D., Ph.D., Professor, /e-mail/ former head of the department of biology, was a leading scientist in the area of yeast protoplast formation, cell wall regeneration and yeast cell morphogenesis. He also studied meiotic division, yeast conjugation, cell fusion and the roles of cytoskeleton in meiosis and in the stress response.
Foreign scientific collaboration:
Masashi Yamaguchi, Ph.D., Associate Professor from Chiba University, Medical Mycology Research Centre, Chiba, Japan, is a world-known expert in electron microscopy and medical mycology.
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