Reseach and Educational Neuroscience Platform




About Masaryk Neuroscience Hub

Are you passionate about research and neuroscience?

Would you like to understand the prenatal programming of brain development?

Do you have a master's degree in Mathematical biology and biomedicine, Bioinformatics, Psychology, or a related field?

Become a PhD student of Neurosciences at the Faculty of Medicine and join our interdisciplinary team working on a prestigious GAČR Junior Star grant!

Paid positions for successful candidates are available immediately. Very good communication skills in Czech are required. 

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Multi-modal and Functional Neuroimaging Research Group is

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Our Latest Research

Distance from main arteries influences microstructural and functional brain tissue characteristics

10 Jan

Distance from main arteries influences microstructural and functional brain tissue characteristics

Given the substantial dependence of neurons on continuous supply of energy, the distribution of major cerebral arteries opens a question whether the distance from the main supply arteries constitutes a modulating factor for the microstructural and functional properties of brain tissue. To tackle this question, multimodal MRI acquisitions of 102 healthy volunteers over the full adult age span were utilised. Relaxation along a fictitious field in the rotating frame of rank n = 4 (RAFF4), adiabatic T1ρ, T2ρ, and intracellular volume fraction (fICVF) derived from diffusion-weighted imaging were implemented to quantify microstructural (cellularity, myelin density, iron concentration) tissue characteristics and degree centrality and fractional amplitude of low-frequency fluctuations to probe for functional metrics. Inverse correlation of arterial distance with robust homogeneity was detected for T1ρ, T2ρ and RAFF4 for cortical grey matter and white matter, showing substantial complex microstructural differences between brain tissue close and farther from main arterial trunks. Albeit with wider variability, functional metrics pointed to increased connectivity and neuronal activity in areas farther from main arteries. Surprisingly, multiple of these microstructural and functional distance-based gradients diminished with higher age, pointing to uniformization of brain tissue with ageing.

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