Pozitivita imunoglobulinu IgG4 v krevním séru u osob s karcinomem slinivky břišní
| Title in English | The serological positivity of immunoglobulin IgG4 in patients with pancreatic carcinoma |
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| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Gastroenterology and hepatology |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.csgh.info/dwnld/gh_2012_3_187_190.pdf |
| Field | Endocrinology, diabetology, metabolism, nutrition |
| Keywords | IgG4; autoimmune pancreatitis; carcinoma of the pancreas |
| Description | The group of illnesses marked by high level of immunoglobulin G4 (IgG4) in blood serum are designated as IgG4-associated diseases. The most common disease in this group is an autoimmune form of pancreatitis. In its initial stage, this is characterised by mild, subjective complaints, which more resemble stomach discomfort. The first symptom, however, may be a painless, obstructive icterus. Imaging methods can be used to view the diffuse or segmental enlargement of the pancreas, which can cause difficulties in distinguishing it from a pancreatic carcinoma. A characteristic feature of the autoimmune form of pancreatitis, and in particular first type, is an increased level of IgG4 of the blood serum, where a 97% specificity and 95% sensitivity predict a diagnosis of the autoimmune form of pancreatitis. Case studies have also appeared in specialist literature showing a high level of IgG4 in patients with a pancreatic carcinoma. In our prospective study, we therefore examined a set of patients with histologically verified pancreatic carcinomas and determined the level of IgG4 in their blood serum. |