Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma

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Authors

TICHÝ Michal KNOPFOVÁ Lucia JARKOVSKÝ Jiří PEKARČÍKOVÁ Lucie VEVERKOVÁ Lenka VLČEK Petr KATOLICKÁ Jana ČAPOV Ivan HERMANOVÁ Markéta ŠMARDA Jan BENEŠ Petr

Year of publication 2016
Type Article in Periodical
Magazine / Source Tumor Biology
MU Faculty or unit

Faculty of Science

Citation
Doi http://dx.doi.org/10.1007/s13277-016-4956-7
Field Genetics and molecular biology
Keywords c-Myb; colorectal carcinoma; immunohistochemistry; metastases; mRNA
Description The MYB gene codes for the c-Myb transcription factor maintaining proliferation of colon epithelial progenitors, thus controlling colon development and homeostasis. This gene is overexpressed in early phases of colorectal cancer (CRC) tumorigenesis. The aim of this study was to examine the expression of c-Myb in CRC tissue samples both at the messenger RNA (mRNA) and protein levels and to evaluate their associations with clinicopathological characteristics in a group of 108 CRC patients. Statistically significant negative association was found between the frequency of the c-Myb-positive tumor cells assessed by immunohistochemistry and the presence of distant metastases but not tumor differentiation, tumor stage, lymph node involvement, vascular invasion, tumor localization, age, and gender of the patients. Although the c-Myb protein level in the tumor tissue correlated with its mRNA level, no significant association between MYB mRNA and any clinicopathological characteristics was observed. We conclude that albeit overexpression of c-Myb is considered as an important factor contributing to early phases of CRC tumorigenesis, it may later have negative effect on tumor cell dissemination as observed recently in breast cancer as well. Further studies are required to explain the role of c-Myb during formation of CRC distant metastases.
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