Apolipoprotein E genotype and traumatic brain injury in children—association with neurological outcome



Year of publication 2007
Type Article in Periodical
Magazine / Source Childs Nerv Syst
MU Faculty or unit

Faculty of Medicine

Field Neurology, neurosurgery, neurosciences
Keywords Brain injuries Child Apolipoprotein E4 Association Glasgow Coma Scale Glasgow Outcome Scale
Description To determine whether the presence of Apolipoprotein E 4 genotype (ApoE 4) is associated with outcomes of traumatic brain injury in children. The ApoE genotype was examined in the group of 70 pediatric patients who suffered from traumatic brain injury. The group consists of 48 boys and 22 girls, and the most frequent was the E3 isoform of ApoE. Polymerase chain reaction/restriction fragment length polymorphism method was used for the ApoE genotype assessment. Our results suggest the association between the ApoE genotype and outcome of traumatic brain injury in children. Patients with ApoE 4 genotype were more likely to have severe clinical symptomatology and unfavorable neurological outcome after traumatic brain injury compared to significantly better outcome with other ApoE genotype.

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