Současné možnosti diagnostiky prekanceróz a karcinomu děložního hrdla
| Title in English | Dysplasia and cervical cancer: current diagnostic posibilities |
|---|---|
| Authors | |
| Year of publication | 2014 |
| Type | Article in Periodical |
| Magazine / Source | Česká gynekologie |
| MU Faculty or unit | |
| Citation | |
| Field | Gynaecology and obstetrics |
| Keywords | cervix uteri; cervical carcinoma; SIL; colposcopy; LBC; HPV; methylation; mRNA |
| Description | Objective: To review current methods in the diagnosis of dysplasias and uterine cervix carcinoma Design: Review article. Setting: Reprofit International Ltd., Brno, Department of Gynecology and Obstetrics, University Hospital and Faculty of Medicine, Masaryk University, Brno, Biopticka laborator Ltd., Pilsen. Methods and results: Nowadays, there are noninvasive methods for more accurate and timely detection of uterine cervix lesions. Digital images of the uterine cervix can be analysed by a computer for characteristics features and colour patterns, which may enhanced the objectivity of the colposcopic examination. Digital image processing technology is useful in liquid based smears (LBC). At the molecular genetic level it is used different tests to detect deoxyor ribonucleic acid (DNA, RNA) of highrisk types human papillomaviruses (High Risk Human Papilloma Virus HPV). However, the accurate identification of cervical highgrade lesions appears mRNA detection of oncogenes E6 and E7. The advanced method for the assessment of cervical lesion development at HR HPV positive women is to determine the methylation of tumor supressor genes that normally prevents the cancer growth. Conclusion: Screening programs, inviting women to direct preventive gynecological examinations by health insurance, but also efficient utilization of available methods will lead to the early detections of cervical dysplasias. |