Expression of VEGF-A by neoplastic cells in T-cell lymphoblastic lymphoma: possible therapeutic implications related to immunomodulatory properties of this cytokine

Authors

KŘENOVÁ Zdenka ŠTĚRBA Jaroslav TVRDÍKOVÁ Eliška KŘEN Leoš

Year of publication 2015
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Background: VEGF-A, well known for its mechanistic angiogenic effect and as a target for antiangiogenic therapeutic drugs, has also potent immunomodulatory characteristics. Namely, it contributes to blockade of dendritic cells maturation and increases a number of regulatory T lymphocytes (Treg’s) in blood and tumor tissues. Conclusion: We found expression of VEGF-A in a majority of cases of T-LL. Because of known immunosuppressive properties of VEGFA, possible adding of antiangiogenic drugs to therapeutic armamentarium in T-LL appears warranted.

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