Electrophysiological biomarkers for deep brain stimulation outcomes in movement disorders: state of the art and future challenges

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This publication doesn't include Faculty of Medicine. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.


Year of publication 2021
Type Article in Periodical
Magazine / Source Journal of Neural Transmission
MU Faculty or unit

Central European Institute of Technology

Web https://link.springer.com/article/10.1007%2Fs00702-021-02381-5
Doi http://dx.doi.org/10.1007/s00702-021-02381-5
Keywords Deep brain stimulation; EEG biomarkers; Local field potentials; Movement disorders
Description Several neurological diseases are accompanied by rhythmic oscillatory dysfunctions in various frequency ranges and disturbed cross-frequency relationships on regional, interregional, and whole brain levels. Knowledge of these disease-specific oscillopathies is important mainly in the context of deep brain stimulation (DBS) therapy. Electrophysiological biomarkers have been used as input signals for adaptive DBS (aDBS) as well as preoperative outcome predictors. As movement disorders, particularly Parkinson's disease (PD), are among the most frequent DBS indications, the current research of DBS is the most advanced in the movement disorders field. We reviewed the literature published mainly between 2010 and 2020 to identify the most important findings concerning the current evolution of electrophysiological biomarkers in DBS and to address future challenges for prospective research.
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