Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors


EEKERS Danielle B P ZEGERS Catharina M L AHMED Kamran A AMELIO Dante GUPTA Tejpal HARRABI Semi Ben KAZDA Tomáš SCARTONI Daniele SEIDEL Clemens SHIH Helen A MINNITI Giuseppe

Year of publication 2024
Type Article in Periodical
MU Faculty or unit

Faculty of Medicine

Keywords brain tumors; chordomas; gliomas; meningiomas; proton beam; radiotherapy; radiosurgery
Description Radiation therapy (RT) plays a fundamental role in the treatment of malignant and benign brain tumors. Current state-of-the-art photon- and proton-based RT combines more conformal dose distribution of target volumes and accurate dose delivery while limiting the adverse radiation effects. PubMed was systematically searched from from 2000 to October 2023 to identify studies reporting outcomes related to treatment of central nervous system (CNS)/skull base tumors with PT in adults. Several studies have demonstrated that proton therapy (PT) provides a reduced dose to healthy brain parenchyma compared with photon-based (xRT) radiation techniques. However, whether dosimetric advantages translate into superior clinical outcomes for different adult brain tumors remains an open question. This review aims at critically reviewing the recent studies on PT in adult patients with brain tumors, including glioma, meningiomas, and chordomas, to explore its potential benefits compared with xRT.

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