Individualizace farmakoterapie inhibitory tymidylát syntázy u nádorů gastrointestinálního traktu

Title in English The individualised pharmacotherapy of gastrointestinal cancer bases on thymidylate synthase inhibitors
Authors

SVOBODA Miroslav SLABÝ Ondřej

Year of publication 2004
Type Article in Periodical
Magazine / Source Klinická farmakologie a farmacie
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.klinickafarmakologie.cz/artkey/far-200403-0006.php
Field Oncology and hematology
Keywords tymidylát syntáza; fluoropyrimidinové deriváty; antifoláty; komplexní profily genové expresew
Description The inhibitors of thymidylate synthase (TS) are frequently used as anticancer drugs. These drugs can be divided into two principal groups: the fluoropyrimidine derivatives and folic acid analogs. All these inhibitors change enzymatic activity of TS, and at the same time they are also metabolizeded by different enzymes. The interindividual differences in the expression and activity of TS and of other enzymes can be exploited in the design of targeted individual anticancer therapy. Unfortunately the drug resistance is influenced by hundreds of genes. If we would like to predict the drug resistance, the determination of as little as several markers would not be probably efficient. The routine establishment of methods of screening expression of tens or hundreds of genes and their protein products will be probably necessary for such prediction.

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