Effects of a persistent sodium current through mutated hNav1.5 sodium channels on intracellular ionic homeostasis in a ventricular cell model
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Proceedings |
| Conference | Computers in cardiology 2005 |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | cardiac cell persistent; sodium current; quantitative modelling |
| Description | In LQT3 patients, SCN5A mutations were found that lead to a small fraction of persistent hNav1.5 current. We explored the effects of such a change on the intracellular ionic homeostasis and arrhythmogenesis in a model of guinea-pig cardiac ventricular cell. |
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