Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma

Authors

ZITTERBART Karel FILKOVÁ Hana TOMÁŠIKOVÁ Lenka NEČESALOVÁ Eva ZAMBO Iva KANTOROVÁ Dagmar SLÁMOVÁ Iva VRANOVÁ Vladimíra ŽEŽULKOVÁ Dita PEŠÁKOVÁ Martina PAVELKA Zdeněk VESELSKÁ Renata KUGLÍK Petr ŠTĚRBA Jaroslav

Year of publication 2011
Type Article in Periodical
Magazine / Source Journal of Neuro-Oncology
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1007/s11060-010-0289-3
Field Oncology and hematology
Keywords medulloblastoma; amplification; gain; MYCN; MYCC; I-FISH
Description Analysis of a cohort of 29 medulloblastoma patients has clearly shown that copy number increases of MYC genes (MYCC, MYCN)are associated with lowered event-free survival and overall survival in MB. In the case of MYCN, this negative correlation was statistically significant.

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