Project information
Proteom extracelulárních vezikul - neprozkoumaná oblast mezibuněčné komunikace v mikroprostředí nádorů hlavy a krku

Project Identification
Project Period
5/2022 - 12/2025
Investor / Pogramme / Project type
Ministry of Health of the CR
MU Faculty or unit
Faculty of Medicine
Cooperating Organization
University Hospital Prague - Motol

Head and neck squamous cell carcinoma (HNSCC) is common and severe solid cancer. Cancer-associated fibroblasts (CAFs) can promote HNSCC progression and therapy resistance by secreting factors contained in exosomes. Exosomes are released from CAFs and other cells in the tumour microenvironment and may increase the invasive behaviour of cancer cells. Exosomal proteins are promising non-invasive biomarkers for many types of cancer as exosomes with tumour-specific proteins can be also detected in the venous blood of cancer patients. In this project, we want to investigate the proteome of CAFs-derived exosomes. We will test the relevance of exosomal proteins as biomarkers for diagnosis, relapse-free survival, and treatment resistance of HNSCC patients indicated for curative surgery and adjuvant chemotherapy. Furthermore, we would like to assemble a set of CAFs-derived exosomal proteins that can be detected also in the venous blood of HNSCC patients and reflect the presence of a malignant tumour or treatment-resistant phenotype.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No.  3 – Good health and well-being Sustainable Development Goal No.  4 – Quality education Sustainable Development Goal No.  5 – Gender equality Sustainable Development Goal No.  8 – Decent work and economic growth Sustainable Development Goal No.  17 – Partnerships for the goals


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