Group leader: Mgr. Lukáš Čajánek, Ph.D.

Postdoc: Dr. Annette Jacobsen, a successful candidate from the University of Melbourne, will focus on the mechanisms and functions of primary cilia.

Group leader: Mgr. Vladimír Rotrekl, Ph.D.

Postdoc: Dr. Michelle Geryk from Nantes University will work on the study of the cardiomyocytes differentiated from patients harbouring cardiac mutations resulting in arrhythmia and/or cardiomyopathy.

Principal investigator: doc. MUDr. Milan Urík, Ph.D.

The aim of this project is to collect data and gain new insight into the pathogenesis of acute otitis media and to significantly modify preventive, diagnostic and therapeutic recommendations.

Principal investigator: prof. MUDr. Marie Nováková, Ph.D.

The aim of the project is to establish and validate a model of doxorubicin cardiotoxicity and to study the effect of an antihypertensive agent and a sigma 1 ligand with a predicted cardioprotective potential.

Principal investigator: Mgr. Zuzana Sumbalová Koledová, Ph.D.

In this project, we aim to develop a toolkit to investigate WNT signaling in mammary fibroblasts in vivo and to obtain conclusive preliminary data on the role of WNT signaling in mammary fibroblasts in epithelial morphogenesis.

Principal investigator: Mgr. Mgr. Katarína Rebrošová

The project focuses on the effects of essential oils in sub-inhibitory concentrations and in plasma on growing bacteria using Raman spectroscopy - a powerful tool that can mirror chemical bonds present in various samples, including bacterial cells or colonies.

Principal investigator: Mgr. Květa Pilařová, Ph.D.

This project focuses on novel functions of Caveolin-1 (Cav-1) and their possible oncogenic properties.

Principal investigator: Ing. Hana Holcová Polanská, Ph.D.

Assessment of response to treatment in the chick chorionic allantoic membrane (CAM) model may represent a useful screening tool for personalized medicine with the potential to improve patient treatment and outcomes.

Principal investigator: Ing. Kateřina Petrláková

The main goal of this project is to find PMS with high migration and antiproliferative potential against cancer cells.

Principal Investigator: RNDr. Jan Balvan, Ph.D.

Jan Jan Balvan, Ph.D. The aim of the project is to investigate the specific and sensitive detection of different types of cell death in vivo to monitor the response of cell population to therapy with specific molecules.

Principal investigator: doc. MUDr. Igor Penka, CSc.

The aim of the project is the possibility of application of nanomaterials on visceral peritoneum, investigation of adhesiveness of specific nanomaterials on this surface, its degradability and at the same time promotion of healing.

Principal Investigator: Mgr. Tomáš Bárta, Ph.D.

In this project, we will use retinal organoids derived from induced pluripotent stem cells (hiPS) as a model to further investigate the effects of hyperglycemia on human retinal development.

Principal investigator: Mgr. Dáša Bohačiaková, Ph.D.

The aim of this project is to discover the mechanisms that lead to the development of Alzheimer's disease.

Principal investigator: Mgr. Júlia Bohošová, Ph.D.

The aim of the project is to investigate microRNAs in perioperative tissue samples and blood plasma as potential factors involved in the development of ASD in patients operated for DDD or degenerative spondylolisthesis with single-segment stabilization, and subsequent possibilities of its prevention or slowing down.

Investigator: doc. Mgr. Jan Křivánek, Ph.D.

Dr. Maryam Azam, the successful candidate, will focus on fundamental aspects of developmental biology and its connection to regenerative medicine, helping the group to unravel the mechanisms involved in maintaining stem cell niche homeostasis, stem cell activation after injury, and the processes controlling cell differentiation at the molecular level.

Principal investigator: prof. RNDr. Monika Pávková Goldbergová, Ph.D.

Dr. Daniel Wojtas will be responsible for the analysis and interpretation of data from various assays, including genomics, methylomics, proteomics and toxicity data. The overarching goal is to elucidate the biological mechanisms controlling healing and immune processes to improve metal incorporation.

Junior group leader: Alemeh Zamani, Ph.D.

Dr. Zamani's junior research group will focus on dysfunctions of the choroid plexus associated with various neurological disorders, including neuroinflammation and neurodegeneration. They will strive to expand knowledge about its pathophysiological mechanisms, particularly in Alzheimer's disease and chemotherapy-induced neuropathy.

Principal investigator: Mgr. Dáša Bohačiaková, Ph.D.

The aim of this project is to use a newly developed model of Glioblastoma multiforme (GBM) cultured using human brain organoids and to identify the molecular mechanisms that are activated after GBM interaction with healthy brain tissue.

Principal investigator: Mgr. Michaela Bosáková, Ph.D.

The aim of the project is to establish a gastruloid/embryoid methodology for the study of receptor tyrosine kinase signalling in the primary cilia and to determine the relevance of this type of signalling for early embryonic development.

Principal Investigator: Mgr. Lukáš Čajánek, PhD.

The aim of the project is to study causality between defective cilia and key processes of embryonic development (proliferation, differentiation). A key attribute of the project is the use of human pluripotent stem cell lines to model these processes in a controlled tissue culture environment.

Principal Investigator: PharmDr. Martin Čulen, Ph.D.

The aim of the project is to extend the experimental capabilities for in vivo models of acute myeloid leukemia (AML) and to test the continuous passaging of primary samples from AML patients in the mouse. The established in vivo AML collection will enable reproducible and nearly unlimited in vivo treatment testing and expansion of primary cells for other purposes that would not be capaciously possible using only vitally frozen samples.

Principal investigator: Mgr. Katarína Chalásová, Ph.D.

The project aims to introduce and optimize for routine use the method of isolation of proximal tubular cells (PTEC) from human urine as (A) a potential diagnostic method ("liquid kidney biopsy") and (B) to obtain pathophysiologically relevant experimental material for the study of diabetic kidney disease.

Principal investigator: Mgr. Zuzana Sumbalová Koledová, Ph.D.

This project develops protocols for quantifying mechanical force in organoid cultures, including micropipette aspiration and laser ablation.

Principal investigator: doc. Mgr. Jan Křivánek, Ph.D.

The aim of the project is to reveal a previously unknown function of an uncharacterized type of mesenchymal stem cells in a continuously growing tooth.

Principal investigator: doc. Mgr. Ondřej Peš, Ph.D.

The aim of the project is longitudinal monitoring of hair cortisol using liquid chromatography-mass spectrometry for determination and comparison of hair cortisol levels in healthy volunteers as well as in indicated patient groups.

Principal Investigator: MUDr. Tibor Stračina, Ph.D.

The aim of the project is to establish and validate a new model of myocardial remodelling induced by aortic ligation in the rat and to determine the effect of social isolation of rats on sigma 1 receptor expression and progression of myocardial remodelling.

Hlavní řešitel: Mgr. Lucie Válková, Ph.D.

Cílem projektu je komplexní hodnocení zánětlivého postižení chrupavky z pohledu metabolických dějů, ovlivnění zánětlivé reakce chondrocytů a redoxních dějů v kontextu vlivu nejběžněji klinicky používaných chondroprotektiv.

Principal Investigator: Mgr. Lucie Válková, Ph.D.

The aim of the project is a comprehensive evaluation of inflammatory cartilage damage in terms of metabolic processes, influence of inflammatory response of chondrocytes and redox processes in the context of the influence of the most commonly used clinical chondroprotective agents.

Principal Investigator: Pavel Krejčí, Ph.D.

The aim of the project of Gustavo Rico, Ph.D. from the University of Malaga, is to determine the expression and role of PDEs in the regulation of disc growth and articular cartilage.