Důsledky vrozených a somatických mutací genů, jejichž produkty se účastní přestavby chromatinu
| Title in English | The effects of germ-line and somatic mutations of genes involved in chromatin remodeling |
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| Authors | |
| Year of publication | 2002 |
| Type | Article in Periodical |
| Magazine / Source | Časopis lékařů českých |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | chromatin remodeling; Rubinstein-Taybi syndrome; Coffin-Lowry syndrome; Williams syndrome; Rett syndrome; tumor suppressors; cancers; leukemia |
| Description | Chromatin remodeling is engaged in basic cell functions as DNA replication, recombination, DNA repair and gene transcription. Chromatin is remodeled by ATP-rependent chromatin remodeling complexes and protein complexes covalently modifiyng histones. Germ-line mutations of the genes coding for proteins which participate in chromatin remodeling cause severe developmental diseases and they increase risk of cancer development. Somatic mutations and translocations of such genes are associated with cancer development of certain tumors. Chromatin remodeling mechanisms can thus be targeted by special strategy of cancer therapy. |
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