Can we detect the development of baroreflex sensitivity in humans between 11 and 20 years of age?
|Year of publication||2006|
|Type||Article in Periodical|
|Magazine / Source||Canadian Journal of Physiology and Pharmacology|
|MU Faculty or unit|
|Keywords||baroreflex sensitivity; spectral analysis; age; adolescents; children|
|Description||The aim of the study was to determine changes of baroreflex sensitivity (BRS/BRSf) in humans between 11 and 20 years of age. Beat-by-beat values of inter-beat intervals (IBI) or heart rate, and systolic and diastolic blood pressures were measured for 5 min in 415 healthy subjects. BRS did not correlate with age, but BRSf significantly decreased (p<0.001). BRS correlated with mean IBI (p<0.001), but BRSf was IBI-independent. Results of multiregression equations were: BRS=1.37-0.56*age+0.02*IBI (p<0.001 for BRS vs. age and for BRS vs. IBI); BRSf=34.74–0.97*age-0.001*IBI (p<0.001 only for BRS vs. age). The limits of BRS: 5th percentile - 3.9 ms/mmHg; 50th - 9.1; 95th - 18.7, and limits for BRSf: 5th percentile - 8.5 mHz/mmHg; 50th - 16.4; 95th - 33.6. Conclusion: IBI-dependent BRS was unchanged in the particular age groups, but the standardization of BRS on IBI was decreased with age. BRSf was IBI-independent and better reflected the development of the baroreflex sensitivity.|