Determination of soluble ST2 by MAP technology
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|MU Faculty or unit
|Production sST2 in cardiomyocytes and fibroblasts is stimulated by myocardial mechanical stress. sST2 is considered a decoy receptor of IL-33 that blocks the protective effect of the cytokine in atherosclerosis and myocardial remodelling. Concentration of sST2 was measured using on the Luminex. We found that in patients with chronic heart failure sST2 values were not significantly elevated.In patients with cardiogenic shock was observed a 50% decrease of sST2 plasma concentration within 96 hours.Current data suggest that sST2 monitoring has primarily prognostic significance.