Non-invasive estimation of arterial stiffness in healthy and asthmatic children: a pilot study.

Authors

TINKA Pavel HANSEN Hedda Asia BUDINSKAYA Ksenia SVÍZELA Vojtěch SVAČINOVÁ Jana RÝDLOVA Jana HRSTKOVÁ Hana DOBŠÁK Petr NOVÁKOVÁ Zuzana

Year of publication 2019
Type Conference abstract
Citation
Description Introduction: Asthma is a chronic airway inflammatory disease that can have potential systemic impact on all organ systems. The “golden” standard for evaluation of cardiovascular system (CVS) functions are parameters: systolic (SBP) and diastolic (DBP) blood pressures and arterial stiffness measurement. The aim of our study: to evaluate functional and structural changes in CVS in asthmatic patients with compare to healthy children. Methods: We measured 52 asthmatic children (group A, 23 boys) and 71 heathy control (group C, 34 boys); age (14±2 years old), body mass index (BMI: 21.1±4.6kg/m2). For each respondent we measured SBP and DBP (Omron, HEM-907-E, Japan). For estimation cardiovascular parameters we used applanation tonometry (Sphygmocor device, AtCor Medical, Australia; vascular parameters: pulse wave velocity-PWV, augmentation pressure-AP and index-AI; parameters of cardiac function: central tension time index-TTI, central diastolic time index-DTI, central Buckberg index-SEVR, [%]. Such vascular parameters as cardio ankle vascular index (CAVI) and ankle brachial index (ABI) were measured on the both side with VaSera device (Fukuda Denshi, Tokyo, Japan. Results: There were significant differences in PWV (6.6±1.1vs.7.2±1.4 m/s; p<0.05), CAVIR (4.4±0.9 vs. 4.8±0.6; p<0.05), CAVIL (4.5±0.7vs.4.9±0.6; p<0.01), ABIL (0.9±0.1vs.0.95±0.1; p<0.01), TTI (1980±282.0vs.1697±334.8; p<0.01), SEVR (135.5±24.2vs.153±37.7 %; p<0.01) between A and C. There is no significant difference in SBP (107.5±13.2 vs. 111±12.4 mmHg; NS) and DBP (62±8 vs. 61±8.7mmHg; NS) between A and C. Conclusion: We can conclude that asthma bronchiale and its treatment changed the properties of vessels in children comparing to the healthy group, as well as parameters of cardiac function.
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