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Project information
Bioartificial 3D graft for intervertebral fusion of the spine

Project Identification
NU20-08-00402
Project Period
5/2020 - 12/2023
Investor / Pogramme / Project type
Ministry of Health of the CR
  • Programme NU (2020 - 2026)
  • Subprogram 1 - standard
MU Faculty or unit
Faculty of Medicine
Cooperating Organization
Brno University of Technology
  • Responsible person Doc. Ing. Klára Částková, Ph.D.

Solid bony fusion is a fundamental prerequisite for the treatment of a wide range of spinal conditions. A graft containing both organic and inorganic components is essential to achieve union. An autograft from a healthy individual possesses an ideal balance of biophysical properties, characterised by its capacity for osteoinduction, osteoconduction and osteogenesis. With advancing age and the presence of comorbidities, these ideal properties diminish; moreover, the harvesting process itself carries a risk of morbidity. At the same time, the quantity of graft available decreases. All allogeneic and artificial substitutes combine biophysical properties with the suppression of osteogenesis. Global data point to the potential of cell therapy. The experimental development outlined in this project combines the development of a three-dimensional porous scaffold with suitable physical properties with the application of human mesenchymal stromal cells and endothelial precursors, with the aim of designing and validating, first in vitro and subsequently in vivo in small animals, the production of an ideal living – bio -artificial – osteogenic scaffold with therapeutic potential for the effective induction of stable intervertebral fusion.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No. 3 – Good health and well-being Sustainable Development Goal No. 5 – Gender equality Sustainable Development Goal No. 17 – Partnerships for the goals

Publications

Total number of publications: 6

2024

2023

2022

2021

  • Bioarteficiální 3D štěp pro meziobratlovou fúzi páteře

    KUČÍREK Martin BENÁK Leoš KOCANDA Jan FILIPOVIČ Milan SKLENSKÝ Jan STREIT Libor VEVERKOVÁ Lenka KOUTNÁ Irena CIHLÁŘ Jaroslav HAMPL Aleš REPKO Martin

    Appeared in Conference without Proceedings

    Year: 2021, type: Appeared in Conference without Proceedings

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