Comparison ASL and DCE-MRI Perfusion Map in Small Animal Model of Cancer
| Authors | |
|---|---|
| Year of publication | 2015 |
| Type | Article in Proceedings |
| Conference | Measurement 2015 : Proceedings of the 10th International Conference on Measurement |
| MU Faculty or unit | |
| Citation | |
| Web | http://hdl.handle.net/11104/0248093 |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | blood flow quantification; ASL; DCE-MRI; Perfusion; Tumour |
| Description | This paper is focused on quantitative perfusion analysis using pulsed ASL (FAIRRARE) and DCE-MRI (using high- and low-molecular-weight contrast agents) in a mouse tumour model. Tumour blood-flow maps of both methods were compared using visual assessment, region analysis (median, percentiles), scatter plots and correlation coefficients. ASL blood-flow estimates matched the DCE-MRI blood-flow estimations in some cases. Possible reasons for poor match in the other cases were investigated. This study indicates that in tumour perfusion analysis, we might profit from the combination of ASL and DCEMRI instead of using just one of them. |