Biopathology of childhood, adolescent and young adult non-Hodgkin lymphoma

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Authors	LIM Megan S FOLEY Michelle MUSSOLIN Lara SIEBERT Reiner TURNER Suzanne Dawn
Year of publication	2023
Type	Article in Periodical
Magazine / Source	BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
MU Faculty or unit	Central European Institute of Technology
Citation
Web	https://www.sciencedirect.com/science/article/pii/S1521692623000087?via%3Dihub
Doi	http://dx.doi.org/10.1016/j.beha.2023.101447
Keywords	Pathobiology; Genetic; Childhood; Adolescent and young adult; Non -Hodgkin lymphoma
Description	Mature non-Hodgkin lymphomas (NHL) in the childhood, adolescent and young adult (CAYA) population are rare and exhibit unique clinical, immunophenotypic and genetic characteristics. Application of large-scale unbiased genomic and proteomic technologies such as gene expression profiling and next generation sequencing (NGS) have led to enhanced understanding of the genetic basis for many lymphomas in adults. However, studies to investigate the pathogenetic events in CAYA population are relatively sparse. Enhanced understanding of the pathobiologic mechanisms involved in non-Hodgkin lymphomas in this unique population will allow for improved recognition of these rare lymphomas. Elucidation of the pathobiologic differences between CAYA and adult lymphomas will also lead to the design of more rational and much needed, less toxic therapies for this population. In this review, we summarize recent insights gained from the proceedings of the recent 7th International CAYA NHL Symposium held in New York City, New York October 20-23, 2022.