Influence of endocannabinoids anandamide and noladin on mouse leukocyte phagocytosis



Year of publication 2002
Type Article in Periodical
Magazine / Source Adiktologie
MU Faculty or unit

Faculty of Medicine

Field Pharmacology and pharmaceutical chemistry
Keywords cannabinoids; anandamide; noladin; leukocyte phagocytosis; chemiluminescence; mice
Description The cannabinoids are involved in regulation of immune function. This action can be mediated either through cannabinoid receptors which subtypes CB1 and CB2 have been identified on leukocytes, or by non-receptor mechanism not clearly understood yet. The present study investigated the influence of the endocannabinoids (anandamide, noladin) on the cellular immune function on leukocyte phagocytosis. Phagocytic activity of mouse leukocytes was measured in chemiluminescence (CL) assay using zymosan induction of phagocytosis and luminol potentiated of CL in vitro.
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