VYUŽITIE ZVIERACIEHO MODELU DEPRESIE PRI OVEROVANÍ ANTIDEPRESÍVNYCH ÚČINKOV FELBAMÁTU
| Title in English | The animal model of depression in testing antidepressant effects of felbamate |
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| Authors | |
| Year of publication | 2003 |
| Type | Article in Proceedings |
| Conference | Abstrakta 47. Studentské vědecké konference |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | felbamate - animal model - antidepressant - olfactory bulbectomy |
| Description | Repeated administration of felbamate (240 mg/kg/day) elicited a significant inhibition of the motor hyperactivity in the rat model of depression (Olfactory Bulbectomy Model), which indicates a potential antidepressant felbamate effects. At the same time, the significantly suppressed leukocyte phagocytosis recorded in bulbectomized rats was disinhibited by felbamate treatment. |
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