Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Chemické listy |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | Genetic polymorphism; CYP2D6; paroxetine; alprazolam; psychiatric patients |
| Description | Dynamics of the paroxetine-induced inhibition of CYP2D6 was followed during the paroxetine therapy in patients using phenotyping and genotyping methods. Another aim of the study was to evaluate the level of the enzyme restoration after discontinuation of the paroxetine treatment. The study has shown that even a profound inhibition of CYP2D6 activity in patients without mutation in the CYP2D6 locus had only minor clinical relevance for treatment effectivity and occurence of adverse effects. |
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