The influence of felbamate on sensitization to methamphetamine behavioural effects in mice.
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | European Neuropsychopharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | behavioural sensitization; methamphetamine; felbamate; mice |
| Description | Numerous studies refer to the important involvement of N-methyl-D-aspartate (NMDA) receptors in the development and expression of behavioural sensitization. Activating antiepileptic drugs of the 3rd generation, such as felbamate (FEL) also invoke psychotropic effects. They may possess attention-enhancing and antidepressant efficacy, cause anxiety, insomnia, and agitation. All pharmacological mechanisms of felbamate are not fully elucidated yet, but many of clinical effects may be related to the inhibition of NMDA currents. The present study focuses on investigation of felbamate influence on sensitization to methamphetamine effects on mouse locomotor/exploratory behaviour in the open field.We desribed prevention of expression of metamphetamine sensitization effect in the mice which received the drug challenge dose combined with felbamate. |
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