Incidence of malignancy occurance in patients treated for infertility with assisted reproduction techniques
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Helen. Jour. Obstet. Gynecol |
| MU Faculty or unit | |
| Citation | |
| Field | Gynaecology and obstetrics |
| Keywords | Malignancy occurance; infertility; assisted reproduction techniques |
| Description | The analysis of potential relation between assisted reproduction teqniques (ART) and enhanced risk of ovarian carcinoma (OC) was explored by data analysis of our University-based clinical register and National Oncology Register of Czech republic (NOR). Analyzed file includes data from 12.527 assisted reproduction treatment cycles performed at 4360 patients within years 1982-2004. After the reported malignancies number assessment from the observed group clinical database (ours and NOR) further processing, statistical analysis and results comparison was followed by the Institute of Health Information and Statistics of the Czech Republic. Statistical significance of malignancy occurance was evaluated using p-value<0.01. In the file of 4360 patients was reported 41 malignancies including 6 OC this is 3.454 times 95%CI[1.625 – 6.715] over the expected incidence to this diseased group of women. NOR offered the control diseased women group by the documented 4.236% rate among the total malignant women. It must be investigated by any reservedness whether the same risk of 3.454 developing OC exists at healthy general population women submitted to infertility treatment (p-value=0.004 Yates correction). |