Změny difúzních parametrů mozku potkana během epileptiformní neuronální aktivity navozené pilokarpinem
| Title in English | Changes of diffusion parameters of rat brain during pilocarpine-induced epilepsy |
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| Authors | |
| Year of publication | 2007 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | The objective of the present work was to determine the diffusion parameters in the brain cortex of adult rats after pilocarpine-induced seizures - an experimental model widely used to study the pathophysiology of epilepsy. We conclude that pathologically increased neuronal activity during pilocarpine-induced seizures causes cell swelling followed by a reduction in the ECS volume fraction, a conclusion supported by the MR results (ADCw decrease). |
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