Význam stanovení NtproBNP a big endotelinu pro diagnostiku chronického srdečního selhání u nemocných v pravidelném hemodialyzačním programu
| Title in English | The importance of determination of Nt-proBNP and big endothelin in diagnosing chronic heart failure in patients on regular haemodialysis treatment |
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| Authors | |
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | Vnitřní lékařství |
| MU Faculty or unit | |
| Citation | |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | congestive heart failure; hemodialysis; neurohumoral activation |
| Description | We have followed 99 patients with end stage renal failure, treated by regular haemodialysis. Chronic renal failure is frequently accompanied by chronic heart failure (over 50 %), especially by heart failure with preserved ejection fraction. Patients treated by regular haemodialysis had a tendency to cardiomegaly (51 %), mild systolic dysfunction of the left ventricle (mean LVEF 53 %) and diastolic dysfunction (88 %) of the hypertrophic left ventricle. They had also activated endothelin and neurohumoral system. Only 3 % of the patients had normal values of Nt-proBNP and big endothelin. The plasma level of Nt-proBNP in haemodialysed patients correlated with cardiothoracic ratio and with ejection fraction. The plasma level of big endothelin correlated only with cardiothoracic ratio. |
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