Brain metabolism and diffusion in the rat cerebral cortex during pilocarpine-induced status epilepticus
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Experimental Neurology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | Diffusion; ADCW; Microdialysis; Pilocarpine; Epilepsy; Glucose; Glutamate; Pyruvate; Lactate; Potassium |
| Description | The real-time iontophoretic method using tetramethylammonium-selective microelectrodes and diffusion-weighted magnetic resonance imaging were used to measure the extracellular space volume fraction, tortuosity and apparent diffusion coefficient of water (ADCW) 240 min after the administration of pilocarpine in urethane-anaesthetized rats. The obtained data were correlated with extracellular lactate, glucose, and glutamate concentrations and the lactate/pyruvate-ratio, determined by intracerebral microdialysis. |
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