Chromocentre integrity and epigenetic marks

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Authors	HARNIČAROVÁ Andrea GALIOVÁ Gabriela LEGARTOVÁ Soňa KOZUBEK Stanislav MATULA Pavel BÁRTOVÁ Eva
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Journal of Structural Biology
MU Faculty or unit	Faculty of Informatics
Citation
Doi	http://dx.doi.org/10.1016/j.jsb.2009.09.007
Field	Genetics and molecular biology
Keywords	SUV39h; epigenetics; histone methylation
Description	The epigenetic modification of histones dictates the formation of euchromatin and heterochromatin domains. We studied the effects of a deficiency of histone methyltransferase, SUV39h, and trichostatin A-dependent hyperacetylation on the structural stability of centromeric clusters, called chromocentres. We did not observe the expected disintegration of chromocentres, but both SUV39h deficiency and hyperacetylation in SUV39h+/+ cells induced the re-positioning of chromocentres closer to the nuclear periphery.
Related projects:	Dynamika a organizace chromosomů během buněčného cyklu v normě a patologii