Novel fucose binding lectin domain from the human pathogen Bukholderia cenocepacia

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Authors

ŠULÁK Ondřej CIOCI Gianluca DELIA Monia IMBERTY Imberty WIMMEROVÁ Michaela

Year of publication 2009
Type Article in Proceedings
Conference Glycoconjugate Journal
MU Faculty or unit

Faculty of Science

Citation
Field Biochemistry
Keywords Superlectin; X ray; Isothermal titration callorimetry; Burkolderia cenocepacia
Description The contribution is focused on the BclC lectin that displays affinity for both fucosylated and mannosylated saccharides. Separate cloning of N- and C terminal parts of the protein showed that while C-terminal part, which is homologous to PA-IIL, displays narrow specificity for mannosylated oligosaccharides, N-terminal part represent a novel lectin domain with strict specificity towards fucosylated oligosaccharides.
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