Současný vývoj cílené terapie nádorů oblasti hlavy a krku
| Title in English | Present stage of development in targeted therapy of head and neck cancer |
|---|---|
| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Farmakoterapie |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | head and neck cancer; targeted therapy; cetuximab; tyrosine kinase inhibitors; angiogenesis inhibitors |
| Description | The therapy of head and neck cancer has lately employed new irradiation techniques, induction chemotherapy, and most notably targeted (biological) therapy – in keeping with our growing understanding of the biology of signal pathways involved in the development and progression of tumours new therapies aimed at targets specific for tumour cells have been discovered and introduced. Of these therapies, best results in the treatment of head and neck cancers were obtained with cetuximab and its combination with radiotherapy and/or chemotherapy. Agents examined in this indication have also included monoclonal antibodies, e.g. panitumumab, tyrosine kinase inhibitors, or angiogenesis inhibitors; ongoing research is involved with other substances as well. In the future, biomarkers are urgently needed that would contribute to individualization and optimisation of therapy. |