MicroRNAs and Prostate Cancer
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Chapter of a book |
| Citation | |
| Description | Prostate cancer is the most frequently diagnosed cancer in men in Western countries. The mechanisms initiating and subsequently supporting growth of this cancer remain largely unknown. Results from recent studies indicate that miRNA expression profiles may distinguish prostate carcinoma from non-neoplastic specimens and further classify tumors according to androgen dependence. In addition, a prognostic significance was attributed to specific miRNA patterns as predictors of clinical recurrence following radical prostatectomy. Finally, therapeutic potential of selected miRNAs were tested on in vitro and in vivo models indicating promising results. This chapter summarizes the current knowledge about miRNA deregulation in prostate cancer disease. |