MicroRNA and Glial Tumors: Tiny Relation with Great Potential

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This publication doesn't include Faculty of Medicine. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.

Authors	ŠÁNA Jiří HAJDÚCH Marian SLABÝ Ondřej
Year of publication	2012
Type	Chapter of a book
MU Faculty or unit	Central European Institute of Technology
Citation
Description	MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been observed in many types of cancers. Altered expression levels of several miRNAs were identified also in gliomas. It was many times showed that miRNAs are involved in core signaling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs have a great potential for oncodiagnostic as well as could be promising therapeutic targets in gliomas.
Related projects:	CEITEC - Central European Institute of Technology