Cancer Biology

Stjepan Uldrijan RG: Cancer Biology

Key Topics:

  • Regulation of the p53 tumour suppressor by oncoproteins MDM2 and MDMX
  • Targeted therapy for malignant melanoma

Institute of Medical Genetics and Genomics

Key Topics:

  • Genome Structure
  • Cancer Genomics
  • Cytogenomics
  • Computational Biology
  • Bioinformatics

Centre for Molecular Medicine - Central European Institute of Technology

Key Topics:

  • The role of non-coding RNAs (microRNAs/lncRNAs) in BCR-signalling and microenvironmental interactions in B cell malignancies (Chronic Lymphocytic Leukemia, B-Cell Lymphomas)
  • The regulation of BCR signaling
  • The regulation and function of CD20
  • Development of novel targeted therapies (miR-therapy, targeting of BCR-signalling/adhesion)
  • Prognostic and predictive markers in hematological malignancies

prof. MUDr. Mgr. Marek Mráz, Ph.D.

Research Group Leader Senior, Marek Mráz Research Group

Phone: +420 549 49 8143

Sabina Ševčíková RG: Monoclonal Gammopathies and their Molecular Origin

Key Topics:

  • Pathogenesis of monoclonal gammopathies, especially multiple myeloma and plasma leukemia
  • Plasma cell leukaemia
  • Liquid biopsies (biopsies of body fluids)

Ondřej Slabý RG: Non-coding RNAs

Key Topics:

  • Biology of the non-coding RNAs (microRNA, PIWI-interacting RNAs, long non-coding RNAs, etc.) and their involvement in carcinogenesis,
  • Roles of non-coding RNAs in solid cancer pathogenesis and identification of new therapeutic targets,
  • Application of non-coding RNAs in solid cancer diagnostics and therapy personalization.

Michal Masařík RG: Cancer Research Lab

Key Topics:

  • Cellular Mechanics
  • “Live-cell” Cancer Biomarkers
  • Cell-death analysis
  • Novel Pharmaceuticals and Nanocarriers Testing and Analysis
  • Biostatistics, Machine Learning and Image Analysis

Department of Comprehensive Cancer Care

Key Topics:

  • MicroRNA and Cancer Research
  • Clinical, laboratory and pathologic predictors of cancer outcome; a special focus on immuno-oncology, angiogenesis and mechanisms of resistance
  • Cancer Biology
  • Real World Data
  • National and international networking and collaboration on European cancer guidelines according to cancer units

doc. MUDr. Igor Kiss, Ph.D., MBA

Department head, Comprehensive Cancer Care Department


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