Project information
Hodnocení endotelové vrstvy rohovky u nositelů kontaktních čoček pomocí endoteliálního mikroskopu (EVELIN)

Project Identification
Project Period
1/2022 - 12/2022
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine
Project Website
endothelial microscope, endothelial cell, contact lens

From the professional literature we know that contact lenses cause morphological changes in the corneal endothelium. The increase of the length of wearing time leads to a significant increase variation in cell size, a decrease of hexagonal cell percentage. More often is present an evident intercellular dark area. The corneal autofluorescence increases and the overall endothelial permeability decreases as a consequence of contact lens wear. Contact lens wear also caused corneal thinning, and the cornea became thinner with increasing duration of contact lens wear. Our aim is to use instrument Specular Microscope CEM-530 (Nidek, Japan) to prove these corneal changes in group of soft contact, RGP and hybrid lenses wearers in comparison with the control group of contact lens non-wearers.


The average number of endothelial cells in the research group was 2607.11 +/- 298.45 cells per mm 2. The average number of endothelial cells in the control group was 2831.94 +/- 523.51 cells per mm 2. We tested these two variables using a T-test, which showed a statistically significant difference (p <0.001). A statistically significant difference in mean endothelial cell count related to patient age and use / non-contact lens use of the two types was demonstrated only in the under-40 group compared to the non-contact and keratoconus group and the keratoconus group using TKC (p = 0, 02). A statistically significant difference in the length of contact lens wear was demonstrated between the keratoconus-free group with or without MCC and the keratoconus group when wearing TKC or HKC for more than 20 years (p = 0.01 and p = 0.02). For HKC users, this difference was still demonstrated after 15 years of wearing (p = 0.001).

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No.  3 – Good health and well-being Sustainable Development Goal No.  4 – Quality education Sustainable Development Goal No.  8 – Decent work and economic growth


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