Project information
MErCuRIC - A Phase Ib/II study of MEK1/2 inhibitor PD-­-0325901 with cMET inhibitor PF-­-02341066 in KRASMT and KRASWT (with aberrant c-­-MET) Colorectal Cancer Patients (MErCuRIC)


This project doesn't include Faculty of Medicine. It includes Faculty of Science. Official project website can be found on
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Project Identification
Project Period
12/2013 - 11/2020
Investor / Pogramme / Project type
European Union
MU Faculty or unit
Faculty of Science
Cooperating Organization
The Queen University of Belfast
University of Oxford
Vall d'Hebron Institute of Oncology
Antwerp University Hospital

MErCuRIC is a pan-­‐European collaboration which assembles European and global leaders with acknowledged expertise in the biology, pathology and clinical management
of CRC. The concept of the MErCuric proposal is to use a personalised medicine clinical
trial strategy to target two key proteins, MEK and MET, which are dysregulated in mCRC. This novel multicentre investigator-­‐led clinical trial, inhibiting both MEK and MET in combination (MEKi)/METi), will improve OS in the stratified mCRC cohort. The comprehensive scientific dissection of disease biology described in this proposal will
not only provide new insights on efficacy, but will also underpin development of new
diagnostic and predictive tools that will inform both current and future efforts of the MErCuRIC consortium to combat mCRC. The Consortium will go beyond the current
state-­‐of-­‐the-­‐art by (i) employing a novel treatment strategy targeting the biology of the disease; (ii) using next generation sequencing (NGS), miRNA and companion diagnostics strategies to identify/stage CRC patient subgroups who will maximally benefit from this novel treatment strategy and (iii) deploying (a) non-­‐invasive detection tools (b) relevant preclinical models to underpin novel stratified solutions for patients with acquired drug-­‐ resistance.


Total number of publications: 2

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